Dust gets all over my motherboard. Probably because of the air flow or static electricity or something. The only real way to get your motherboard nice and clean is to spray all the nooks and crannies with compressed air.
Manufacturers should install a simple loop of pipe around all the parts on the motherboard with appropriately spaced holes so that a single burst of compressed air can loosen all the dust particles quickly and effectively. Users may then proceed to vacuum up all the debris before it settles again.